Objective: The study was aimed to determine the prevalence of malaria in Halaba special district, Southern Ethiopia, from 2013-2017.
Results: Of thea total, 583,668, malaria suspectedmalaria-suspected cases examined during the study period, 55, 252 (9.5%) were microscopically confirmed to be positive for malaria, withat the rate of 27,712 (50.2%) females and 27,540 (49.8%) males (P=0.95). The highest prevalence of 8,454 (15.3%) of malaria cases were observed in Halaba health centerHealth Center, followed by Halaba district hospitalDistrict Hospital, at 7,290 (13.2%), while the lowest cases, 1,765 (3.2%), were confirmed in Wejago health centerHealth Center. The highest 25,716(46.5%) prevalence of malaria, 25,716 (46.5%), was registered among the age group ≥15 year old (P=0.006). P. vivax and P. falciparum were the two major malaria parasites detected in this study, with the prevalence of 33,855 (62.3%) and 21,397 (38.7%), respectively (P=0.0001). The detected high prevalence of P. vivax in this study may be clearly indicatingindicate that more attention has been given to control P. falciparum strains in the study area. This may be a great challenge for the achievement of malaria elimination goals. Therefore, all concerned bodies should act collaboratively to combat the high prevalence of P. vivax from the study district.